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KMID : 0370219710150010016
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Yakhak Hoeji
1971 Volume.15 No. 1 p.16 ~ p.21
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Studies on the Synthesis and Antitumor Actiities of Potential Antineoplastic Agents. IV. Synthesis and Antitumor Activities of N-Substituted-p-Arsanilic Acid
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정원근/Chung WK
정문우/김정협/이남복/Chung MW/Kim CH/Lee NB
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Abstract
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Seven organic arsine compounds are synthesized as potential anti-tumor agents are subjected to the screening test of activity against SN-36 Leukemia, Sarcoma 180 and Ehrlich ascites carcinoma. Three compounds, namely N-(5-Nitrofroyl)-p-arsanilic acid. N-(2,4-Dihydroxybenzoethyl)-p-arsanilic acid and N-alpha(p-arsanilide)acetyl thiourea of the all synthesized compounds showed comparatively potential activities against experimental ascitic tumors both through cytological findings and survival duration.
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KEYWORD
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